An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris

The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconaz...

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Autores principales: Kali R. Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M. Pimentel-Elardo, Jen L. Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, José F. Muñoz, Sang Hu Kim, John A. Porco, Christina A. Cuomo, Noelle S. Williams, Ashraf S. Ibrahim, John E. Edwards, David R. Andes, Justin R. Nodwell, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2c173732359e4b30bf7d56530b8aca91
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spelling oai:doaj.org-article:2c173732359e4b30bf7d56530b8aca912021-12-02T13:57:33ZAn oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris10.1038/s41467-020-20183-32041-1723https://doaj.org/article/2c173732359e4b30bf7d56530b8aca912020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20183-3https://doaj.org/toc/2041-1723The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconazole accumulation.Kali R. IyerKaddy CamaraMartin Daniel-IvadRichard TrillesSheila M. Pimentel-ElardoJen L. FossenKaren MarchilloZhongle LiuShakti SinghJosé F. MuñozSang Hu KimJohn A. PorcoChristina A. CuomoNoelle S. WilliamsAshraf S. IbrahimJohn E. EdwardsDavid R. AndesJustin R. NodwellLauren E. BrownLuke WhitesellNicole RobbinsLeah E. CowenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kali R. Iyer
Kaddy Camara
Martin Daniel-Ivad
Richard Trilles
Sheila M. Pimentel-Elardo
Jen L. Fossen
Karen Marchillo
Zhongle Liu
Shakti Singh
José F. Muñoz
Sang Hu Kim
John A. Porco
Christina A. Cuomo
Noelle S. Williams
Ashraf S. Ibrahim
John E. Edwards
David R. Andes
Justin R. Nodwell
Lauren E. Brown
Luke Whitesell
Nicole Robbins
Leah E. Cowen
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
description The fungal pathogen Candida auris is resistant to multiple drugs including the common antifungal fluconazole. Here, Iyer et al. identify a compound that potentiates fluconazole activity against C. auris in vitro and in vivo by inhibiting a major efflux pump and thus increasing intracellular fluconazole accumulation.
format article
author Kali R. Iyer
Kaddy Camara
Martin Daniel-Ivad
Richard Trilles
Sheila M. Pimentel-Elardo
Jen L. Fossen
Karen Marchillo
Zhongle Liu
Shakti Singh
José F. Muñoz
Sang Hu Kim
John A. Porco
Christina A. Cuomo
Noelle S. Williams
Ashraf S. Ibrahim
John E. Edwards
David R. Andes
Justin R. Nodwell
Lauren E. Brown
Luke Whitesell
Nicole Robbins
Leah E. Cowen
author_facet Kali R. Iyer
Kaddy Camara
Martin Daniel-Ivad
Richard Trilles
Sheila M. Pimentel-Elardo
Jen L. Fossen
Karen Marchillo
Zhongle Liu
Shakti Singh
José F. Muñoz
Sang Hu Kim
John A. Porco
Christina A. Cuomo
Noelle S. Williams
Ashraf S. Ibrahim
John E. Edwards
David R. Andes
Justin R. Nodwell
Lauren E. Brown
Luke Whitesell
Nicole Robbins
Leah E. Cowen
author_sort Kali R. Iyer
title An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
title_short An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
title_full An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
title_fullStr An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
title_full_unstemmed An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
title_sort oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen candida auris
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2c173732359e4b30bf7d56530b8aca91
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