Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice
Abstract Chromosomal instability (CIN) is a hallmark of cancer, leading to aneuploid cells. To study the role that CIN plays in tumor evolution, several mouse models have been engineered over the last 2 decades. These models have unequivocally shown that systemic high-grade CIN is embryonic lethal....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/2ee0cafcaa344471b97c2a117ffcebdc |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|