DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the i...

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Main Authors: Takeshi Yamamoto, Yusuke Endo, Atsushi Onodera, Kiyoshi Hirahara, Hikari K. Asou, Takahiro Nakajima, Toshio Kanno, Yasuo Ouchi, Satoshi Uematsu, Hiroshi Nishimasu, Osamu Nureki, Damon J. Tumes, Naoki Shimojo, Toshinori Nakayama
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/2fa4e1b6bbf74a90bf17ce9936a84fec
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