Embeddings from deep learning transfer GO annotations beyond homology

Abstract Knowing protein function is crucial to advance molecular and medical biology, yet experimental function annotations through the Gene Ontology (GO) exist for fewer than 0.5% of all known proteins. Computational methods bridge this sequence-annotation gap typically through homology-based anno...

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Bibliographic Details
Main Authors: Maria Littmann, Michael Heinzinger, Christian Dallago, Tobias Olenyi, Burkhard Rost
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/30047864d85f4054b8b99879adff217c
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