Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and export.

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Autores principales:	Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
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spelling	oai:doaj.org-article:30325ebc8f1440eb95a7ef787cbdca692021-12-02T17:31:08ZPan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway10.1038/s41467-020-15440-42041-1723https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca692020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15440-4https://doaj.org/toc/2041-1723Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and export.Gregory M. LaMonteFrances RocamoraDanushka S. MarapanaNina F. GnädigSabine OttilieMadeline R. LuthTilla S. WorgallGregory M. GoldgofRoxanne MohunlalT. R. Santha KumarJennifer K. ThompsonEdgar VigilJennifer YangDylan HutsonTrevor JohnsonJianbo HuangRoy M. WilliamsBing Yu ZouAndrea L. CheungPrianka KumarTimothy J. EganMarcus C. S. LeeDionicio SiegelAlan F. CowmanDavid A. FidockElizabeth A. WinzelerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory M. LaMonte Frances Rocamora Danushka S. Marapana Nina F. Gnädig Sabine Ottilie Madeline R. Luth Tilla S. Worgall Gregory M. Goldgof Roxanne Mohunlal T. R. Santha Kumar Jennifer K. Thompson Edgar Vigil Jennifer Yang Dylan Hutson Trevor Johnson Jianbo Huang Roy M. Williams Bing Yu Zou Andrea L. Cheung Prianka Kumar Timothy J. Egan Marcus C. S. Lee Dionicio Siegel Alan F. Cowman David A. Fidock Elizabeth A. Winzeler Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
description	Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and export.
format	article
author	Gregory M. LaMonte Frances Rocamora Danushka S. Marapana Nina F. Gnädig Sabine Ottilie Madeline R. Luth Tilla S. Worgall Gregory M. Goldgof Roxanne Mohunlal T. R. Santha Kumar Jennifer K. Thompson Edgar Vigil Jennifer Yang Dylan Hutson Trevor Johnson Jianbo Huang Roy M. Williams Bing Yu Zou Andrea L. Cheung Prianka Kumar Timothy J. Egan Marcus C. S. Lee Dionicio Siegel Alan F. Cowman David A. Fidock Elizabeth A. Winzeler
author_facet	Gregory M. LaMonte Frances Rocamora Danushka S. Marapana Nina F. Gnädig Sabine Ottilie Madeline R. Luth Tilla S. Worgall Gregory M. Goldgof Roxanne Mohunlal T. R. Santha Kumar Jennifer K. Thompson Edgar Vigil Jennifer Yang Dylan Hutson Trevor Johnson Jianbo Huang Roy M. Williams Bing Yu Zou Andrea L. Cheung Prianka Kumar Timothy J. Egan Marcus C. S. Lee Dionicio Siegel Alan F. Cowman David A. Fidock Elizabeth A. Winzeler
author_sort	Gregory M. LaMonte
title	Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
title_short	Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
title_full	Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
title_fullStr	Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
title_full_unstemmed	Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
title_sort	pan-active imidazolopiperazine antimalarials target the plasmodium falciparum intracellular secretory pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
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Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

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