Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and export.
Guardado en:
Autores principales: | Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum
por: Claudia Tapia-Alveal, et al.
Publicado: (2020) -
Protein Kinase A Is Essential for Invasion of <named-content content-type="genus-species">Plasmodium falciparum</named-content> into Human Erythrocytes
por: Mary-Louise Wilde, et al.
Publicado: (2019) -
Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation
por: Zhiqiang Li, et al.
Publicado: (2021) -
4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
por: Niall D. Geoghegan, et al.
Publicado: (2021) -
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>
por: Laure Dumont, et al.
Publicado: (2019)