RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)

RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs)

Background: We have previously shown that overexpression of RANK-c in ER-negative breast cancer cell lines attenuates aggressive properties of cancer cells, partially through a RANK-c/EGFR interaction. EGFR inhibition through TKIs in breast cancer has been tested in triple-negative disease settings...

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Détails bibliographiques
Auteurs principaux: Chaido Sirinian, Anastasios D. Papanastasiou, Soren E. Degn, Theodora Frantzi, Christos Aronis, Dimitrios Chaniotis, Thomas Makatsoris, Angelos Koutras, Haralabos P. Kalofonos
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
breast cancer
ER-negative
EGFR
TKIs
RANK-c
Genetics
QH426-470
Accès en ligne:https://doaj.org/article/30d05a3f504f497184a3252e2af9cfdd
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