Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
The genome is folded in 3-dimensions, though the lack of robust ultra-resolution imaging makes this difficult to visualise. Here, the authors present 3D-EMISH that combines serial block-face scanning electron microscopy with in situ hybridization.
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Main Authors: | , , , , , , , , , , , , , , , , , , |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
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Subjects: | |
Online Access: | https://doaj.org/article/314efe399d9e425fbc4fd722009456ec |
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