DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14<sup>+</sup> CD16<sup>+</sup> CD64<sup>high</sup> CD32<sup>low</sup> Inflammatory Monocytes from Malaria Patients

DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14<sup>+</sup> CD16<sup>+</sup> CD64<sup>high</sup> CD32<sup>low</sup> Inflammatory Monocytes from Malaria Patients

ABSTRACT High levels of circulating immunocomplexes (ICs) are found in patients with either infectious or sterile inflammation. We report that patients with either Plasmodium falciparum or Plasmodium vivax malaria have increased levels of circulating anti-DNA antibodies and ICs containing parasite D...

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Main Authors: Isabella C. Hirako, Carolina Gallego-Marin, Marco A. Ataide, Warrison A. Andrade, Humberto Gravina, Bruno C. Rocha, Rosane B. de Oliveira, Dhelio B. Pereira, Joseph Vinetz, Betty Diamond, Sanjay Ram, Douglas T. Golenbock, Ricardo T. Gazzinelli
Format: article
Language:EN
Published: American Society for Microbiology 2015
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/33ef047a24c34bcc87c54300905ab770
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