A protein tertiary structure mimetic modulator of the Hippo signalling pathway

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.

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Autores principales: Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/34105208594045348e3822ea97b488f7
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https://doaj.org/article/34105208594045348e3822ea97b488f7

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