A protein tertiary structure mimetic modulator of the Hippo signalling pathway
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.
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Nature Portfolio
2020
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oai:doaj.org-article:34105208594045348e3822ea97b488f72021-12-02T17:32:25ZA protein tertiary structure mimetic modulator of the Hippo signalling pathway10.1038/s41467-020-19224-82041-1723https://doaj.org/article/34105208594045348e3822ea97b488f72020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19224-8https://doaj.org/toc/2041-1723Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.Hélène AdihouRanganath GopalakrishnanTim FörsterStéphanie M. GuéretRaphael GasperStefan GeschwindnerCarmen Carrillo GarcíaHacer KaratasAjaybabu V. PobbatiMercedes Vazquez‐ChantadaPaul DaveyCarola M. WassvikJeremy Kah Sheng PangBoon Seng SohWanjin HongElisabetta ChiarparinDennis SchadeAlleyn T. PlowrightEric ValeurMalin LemurellTom N. GrossmannHerbert WaldmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hélène Adihou Ranganath Gopalakrishnan Tim Förster Stéphanie M. Guéret Raphael Gasper Stefan Geschwindner Carmen Carrillo García Hacer Karatas Ajaybabu V. Pobbati Mercedes Vazquez‐Chantada Paul Davey Carola M. Wassvik Jeremy Kah Sheng Pang Boon Seng Soh Wanjin Hong Elisabetta Chiarparin Dennis Schade Alleyn T. Plowright Eric Valeur Malin Lemurell Tom N. Grossmann Herbert Waldmann A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| description |
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells. |
| format |
article |
| author |
Hélène Adihou Ranganath Gopalakrishnan Tim Förster Stéphanie M. Guéret Raphael Gasper Stefan Geschwindner Carmen Carrillo García Hacer Karatas Ajaybabu V. Pobbati Mercedes Vazquez‐Chantada Paul Davey Carola M. Wassvik Jeremy Kah Sheng Pang Boon Seng Soh Wanjin Hong Elisabetta Chiarparin Dennis Schade Alleyn T. Plowright Eric Valeur Malin Lemurell Tom N. Grossmann Herbert Waldmann |
| author_facet |
Hélène Adihou Ranganath Gopalakrishnan Tim Förster Stéphanie M. Guéret Raphael Gasper Stefan Geschwindner Carmen Carrillo García Hacer Karatas Ajaybabu V. Pobbati Mercedes Vazquez‐Chantada Paul Davey Carola M. Wassvik Jeremy Kah Sheng Pang Boon Seng Soh Wanjin Hong Elisabetta Chiarparin Dennis Schade Alleyn T. Plowright Eric Valeur Malin Lemurell Tom N. Grossmann Herbert Waldmann |
| author_sort |
Hélène Adihou |
| title |
A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| title_short |
A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| title_full |
A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| title_fullStr |
A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| title_full_unstemmed |
A protein tertiary structure mimetic modulator of the Hippo signalling pathway |
| title_sort |
protein tertiary structure mimetic modulator of the hippo signalling pathway |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/34105208594045348e3822ea97b488f7 |
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