Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing antibody (NAb) responses in rabbits. The...

Full description

Saved in:
Bibliographic Details
Main Authors: Kwinten Sliepen, Edith Schermer, Ilja Bontjer, Judith A. Burger, Réka Felfödiné Lévai, Philipp Mundsperger, Philip J. M. Brouwer, Monica Tolazzi, Atilla Farsang, Dietmar Katinger, John P. Moore, Gabriella Scarlatti, Robin J. Shattock, Quentin J. Sattentau, Rogier W. Sanders
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/3493c21b5fee4dc2a902a4cfd21185c1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items