Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The phenotypes observed in loss of expression studies are complex with perinatal lethality, stunted growth from weaning, and significant alteration...

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Bibliographic Details
Main Authors: Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Genetics
QH426-470
Online Access:https://doaj.org/article/3524d8cdac74414d80af2322999a4376
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https://doaj.org/article/3524d8cdac74414d80af2322999a4376

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