Full design automation of multi-state RNA devices to program gene expression using energy-based optimization.

Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 5' untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair interaction energies, to design multi-state sRNA devices by solving an optimization p...

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Autores principales: Guillermo Rodrigo, Thomas E Landrain, Eszter Majer, José-Antonio Daròs, Alfonso Jaramillo
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/36ff29ef71b04a09b075c750b2a94d3a
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