A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology

A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology

A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.

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Auteurs principaux: Eric A. Hungate, Sapana R. Vora, Eric R. Gamazon, Takaya Moriyama, Timothy Best, Imge Hulur, Younghee Lee, Tiffany-Jane Evans, Eva Ellinghaus, Martin Stanulla, Jéremie Rudant, Laurent Orsi, Jacqueline Clavel, Elizabeth Milne, Rodney J. Scott, Ching-Hon Pui, Nancy J. Cox, Mignon L. Loh, Jun J. Yang, Andrew D. Skol, Kenan Onel
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Science
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Accès en ligne:https://doaj.org/article/3b8c31642c1f4f19aeefef51e4219d06
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https://doaj.org/article/3b8c31642c1f4f19aeefef51e4219d06

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