A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology
A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.
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Nature Portfolio
2016
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oai:doaj.org-article:3b8c31642c1f4f19aeefef51e4219d062021-12-02T16:50:13ZA variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology10.1038/ncomms106352041-1723https://doaj.org/article/3b8c31642c1f4f19aeefef51e4219d062016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10635https://doaj.org/toc/2041-1723A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.Eric A. HungateSapana R. VoraEric R. GamazonTakaya MoriyamaTimothy BestImge HulurYounghee LeeTiffany-Jane EvansEva EllinghausMartin StanullaJéremie RudantLaurent OrsiJacqueline ClavelElizabeth MilneRodney J. ScottChing-Hon PuiNancy J. CoxMignon L. LohJun J. YangAndrew D. SkolKenan OnelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
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EN |
| topic |
Science Q |
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Science Q Eric A. Hungate Sapana R. Vora Eric R. Gamazon Takaya Moriyama Timothy Best Imge Hulur Younghee Lee Tiffany-Jane Evans Eva Ellinghaus Martin Stanulla Jéremie Rudant Laurent Orsi Jacqueline Clavel Elizabeth Milne Rodney J. Scott Ching-Hon Pui Nancy J. Cox Mignon L. Loh Jun J. Yang Andrew D. Skol Kenan Onel A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| description |
A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b. |
| format |
article |
| author |
Eric A. Hungate Sapana R. Vora Eric R. Gamazon Takaya Moriyama Timothy Best Imge Hulur Younghee Lee Tiffany-Jane Evans Eva Ellinghaus Martin Stanulla Jéremie Rudant Laurent Orsi Jacqueline Clavel Elizabeth Milne Rodney J. Scott Ching-Hon Pui Nancy J. Cox Mignon L. Loh Jun J. Yang Andrew D. Skol Kenan Onel |
| author_facet |
Eric A. Hungate Sapana R. Vora Eric R. Gamazon Takaya Moriyama Timothy Best Imge Hulur Younghee Lee Tiffany-Jane Evans Eva Ellinghaus Martin Stanulla Jéremie Rudant Laurent Orsi Jacqueline Clavel Elizabeth Milne Rodney J. Scott Ching-Hon Pui Nancy J. Cox Mignon L. Loh Jun J. Yang Andrew D. Skol Kenan Onel |
| author_sort |
Eric A. Hungate |
| title |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| title_short |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| title_full |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| title_fullStr |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| title_full_unstemmed |
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology |
| title_sort |
variant at 9p21.3 functionally implicates cdkn2b in paediatric b-cell precursor acute lymphoblastic leukaemia aetiology |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/3b8c31642c1f4f19aeefef51e4219d06 |
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