Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.

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Detalles Bibliográficos
Autores principales: Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander N. Shoushtari, Michael H. Goldbaum, Paul S. Mischel, Samuel F. Bakhoum, Ashley M. Laughney
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d
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https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d

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