Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander N. Shoushtari, Michael H. Goldbaum, Paul S. Mischel, Samuel F. Bakhoum, Ashley M. Laughney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3bfb2543650b4dffa2fb1404ab14b57d
record_format	dspace
spelling	oai:doaj.org-article:3bfb2543650b4dffa2fb1404ab14b57d2021-12-02T18:02:32ZLoss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression10.1038/s41467-021-25529-z2041-1723https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25529-zhttps://doaj.org/toc/2041-1723The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.Mathieu F. BakhoumJasmine H. FrancisAlbert AgustinusEthan M. EarlieMelody Di BonaDavid H. AbramsonMercedes DuranIgnas MasilionisElsa MolinaAlexander N. ShoushtariMichael H. GoldbaumPaul S. MischelSamuel F. BakhoumAshley M. LaughneyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathieu F. Bakhoum Jasmine H. Francis Albert Agustinus Ethan M. Earlie Melody Di Bona David H. Abramson Mercedes Duran Ignas Masilionis Elsa Molina Alexander N. Shoushtari Michael H. Goldbaum Paul S. Mischel Samuel F. Bakhoum Ashley M. Laughney Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
description	The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.
format	article
author	Mathieu F. Bakhoum Jasmine H. Francis Albert Agustinus Ethan M. Earlie Melody Di Bona David H. Abramson Mercedes Duran Ignas Masilionis Elsa Molina Alexander N. Shoushtari Michael H. Goldbaum Paul S. Mischel Samuel F. Bakhoum Ashley M. Laughney
author_facet	Mathieu F. Bakhoum Jasmine H. Francis Albert Agustinus Ethan M. Earlie Melody Di Bona David H. Abramson Mercedes Duran Ignas Masilionis Elsa Molina Alexander N. Shoushtari Michael H. Goldbaum Paul S. Mischel Samuel F. Bakhoum Ashley M. Laughney
author_sort	Mathieu F. Bakhoum
title	Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
title_short	Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
title_full	Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
title_fullStr	Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
title_full_unstemmed	Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
title_sort	loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d
work_keys_str_mv	AT mathieufbakhoum lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT jasminehfrancis lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT albertagustinus lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT ethanmearlie lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT melodydibona lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT davidhabramson lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT mercedesduran lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT ignasmasilionis lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT elsamolina lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT alexandernshoushtari lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT michaelhgoldbaum lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT paulsmischel lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT samuelfbakhoum lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression AT ashleymlaughney lossofpolycombrepressivecomplex1activityandchromosomalinstabilitydriveuvealmelanomaprogression
_version_	1718378861217972224

Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Ejemplares similares