Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression

The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.

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Bibliographic Details
Main Authors: Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander N. Shoushtari, Michael H. Goldbaum, Paul S. Mischel, Samuel F. Bakhoum, Ashley M. Laughney
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d
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