Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing.

Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing.

Molecular mechanisms for the establishment of transcriptional memory are poorly understood. 5,6-dichloro-1-D-ribofuranosyl-benzimidazole (DRB) is a P-TEFb kinase inhibitor that artificially induces the poised RNA polymerase II (RNAPII), thereby manifesting intermediate steps for the establishment of...

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Bibliographic Details
Main Authors: Hitomi Miyazaki, Ken Higashimoto, Yukari Yada, Takaho A Endo, Jafar Sharif, Toshiharu Komori, Masashi Matsuda, Yoko Koseki, Manabu Nakayama, Hidenobu Soejima, Hiroshi Handa, Haruhiko Koseki, Susumu Hirose, Kenichi Nishioka
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Genetics
QH426-470
Online Access:https://doaj.org/article/3ee68ac1ba8943e2b8344a2f9d326ec5
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