TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cell...

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Autores principales: Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba
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