TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3eec8884c2534e3ab8b673a78e5f82ba
record_format	dspace
spelling	oai:doaj.org-article:3eec8884c2534e3ab8b673a78e5f82ba2021-12-02T16:50:08ZTMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins10.1038/s41467-018-05013-x2041-1723https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05013-xhttps://doaj.org/toc/2041-1723One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cells, increasing metastatic spreading.Samrat T. KunduCaitlin L. GrzeskowiakJared J. FradetteLaura A. GibsonLeticia B. RodriguezChad J. CreightonKenneth L. ScottDon L. GibbonsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samrat T. Kundu Caitlin L. Grzeskowiak Jared J. Fradette Laura A. Gibson Leticia B. Rodriguez Chad J. Creighton Kenneth L. Scott Don L. Gibbons TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
description	One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cells, increasing metastatic spreading.
format	article
author	Samrat T. Kundu Caitlin L. Grzeskowiak Jared J. Fradette Laura A. Gibson Leticia B. Rodriguez Chad J. Creighton Kenneth L. Scott Don L. Gibbons
author_facet	Samrat T. Kundu Caitlin L. Grzeskowiak Jared J. Fradette Laura A. Gibson Leticia B. Rodriguez Chad J. Creighton Kenneth L. Scott Don L. Gibbons
author_sort	Samrat T. Kundu
title	TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
title_short	TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
title_full	TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
title_fullStr	TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
title_full_unstemmed	TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
title_sort	tmem106b drives lung cancer metastasis by inducing tfeb-dependent lysosome synthesis and secretion of cathepsins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba
work_keys_str_mv	AT samrattkundu tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT caitlinlgrzeskowiak tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT jaredjfradette tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT lauraagibson tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT leticiabrodriguez tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT chadjcreighton tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT kennethlscott tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins AT donlgibbons tmem106bdriveslungcancermetastasisbyinducingtfebdependentlysosomesynthesisandsecretionofcathepsins
_version_	1718383093797093376

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

Ejemplares similares