TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impacts cell migration and invasion of lung cancer cell...
Enregistré dans:
Auteurs principaux: | Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes
par: Rose Willett, et autres
Publié: (2017) -
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
par: Caitlin L. Grzeskowiak, et autres
Publié: (2018) -
TFEB Dependent Autophagy-Lysosomal Pathway: An Emerging Pharmacological Target in Sepsis
par: Xin Liu, et autres
Publié: (2021) -
TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
par: Nicola Alesi, et autres
Publié: (2021) -
ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer
par: Roxsan Manshouri, et autres
Publié: (2019)