Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand break...

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Main Authors: Hana Hanzlikova, Evgeniia Prokhorova, Katerina Krejcikova, Zuzana Cihlarova, Ilona Kalasova, Jan Kubovciak, Jana Sachova, Richard Hailstone, Jan Brazina, Shereen Ghosh, Sebahattin Cirak, Joseph G. Gleeson, Ivan Ahel, Keith W. Caldecott
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/412587429a3944ccb397a069e9334d8c
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https://doaj.org/article/412587429a3944ccb397a069e9334d8c

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