Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

A variety of biological differences exist between strains and phylogenetic lineages in the Mycobacterium tuberculosis complex (MTBC). Here, the authors perform RNAseq and methylome analysis of the main clades of the MTBC and show variation in transcriptional profiles is mainly due to mutations in tr...

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Autores principales:	Álvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/420da98a568148859292e03efed69a7b
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spelling	oai:doaj.org-article:420da98a568148859292e03efed69a7b2021-12-02T14:39:41ZGenome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex10.1038/s41467-019-11948-62041-1723https://doaj.org/article/420da98a568148859292e03efed69a7b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11948-6https://doaj.org/toc/2041-1723A variety of biological differences exist between strains and phylogenetic lineages in the Mycobacterium tuberculosis complex (MTBC). Here, the authors perform RNAseq and methylome analysis of the main clades of the MTBC and show variation in transcriptional profiles is mainly due to mutations in transcriptional start sites.Álvaro Chiner-OmsMichael BerneyChristine BoinettFernando González-CandelasDouglas B. YoungSebastien GagneuxWilliam R. JacobsJulian ParkhillTeresa CortesIñaki ComasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Álvaro Chiner-Oms Michael Berney Christine Boinett Fernando González-Candelas Douglas B. Young Sebastien Gagneux William R. Jacobs Julian Parkhill Teresa Cortes Iñaki Comas Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
description	A variety of biological differences exist between strains and phylogenetic lineages in the Mycobacterium tuberculosis complex (MTBC). Here, the authors perform RNAseq and methylome analysis of the main clades of the MTBC and show variation in transcriptional profiles is mainly due to mutations in transcriptional start sites.
format	article
author	Álvaro Chiner-Oms Michael Berney Christine Boinett Fernando González-Candelas Douglas B. Young Sebastien Gagneux William R. Jacobs Julian Parkhill Teresa Cortes Iñaki Comas
author_facet	Álvaro Chiner-Oms Michael Berney Christine Boinett Fernando González-Candelas Douglas B. Young Sebastien Gagneux William R. Jacobs Julian Parkhill Teresa Cortes Iñaki Comas
author_sort	Álvaro Chiner-Oms
title	Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
title_short	Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
title_full	Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
title_fullStr	Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
title_full_unstemmed	Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
title_sort	genome-wide mutational biases fuel transcriptional diversity in the mycobacterium tuberculosis complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/420da98a568148859292e03efed69a7b
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Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

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