Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better und...
Guardado en:
Autores principales: | , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/443aebd51a024799afe9304b404255fe |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:443aebd51a024799afe9304b404255fe |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:443aebd51a024799afe9304b404255fe2021-12-02T12:40:39ZSubmolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism10.1038/s42003-020-01518-82399-3642https://doaj.org/article/443aebd51a024799afe9304b404255fe2020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01518-8https://doaj.org/toc/2399-3642Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better understanding of GPCR activation and signalling.Andra C. DumitruR. N. V. Krishna DeepakHeng LiuMelanie KoehlerCheng ZhangHao FanDavid AlsteensNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-13 (2020) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Biology (General) QH301-705.5 |
spellingShingle |
Biology (General) QH301-705.5 Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
description |
Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better understanding of GPCR activation and signalling. |
format |
article |
author |
Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens |
author_facet |
Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens |
author_sort |
Andra C. Dumitru |
title |
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
title_short |
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
title_full |
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
title_fullStr |
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
title_full_unstemmed |
Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
title_sort |
submolecular probing of the complement c5a receptor–ligand binding reveals a cooperative two-site binding mechanism |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/443aebd51a024799afe9304b404255fe |
work_keys_str_mv |
AT andracdumitru submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT rnvkrishnadeepak submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT hengliu submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT melaniekoehler submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT chengzhang submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT haofan submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism AT davidalsteens submolecularprobingofthecomplementc5areceptorligandbindingrevealsacooperativetwositebindingmechanism |
_version_ |
1718393735173111808 |