Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better und...

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Auteurs principaux:	Andra C. Dumitru, R. N. V. Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/443aebd51a024799afe9304b404255fe
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spelling	oai:doaj.org-article:443aebd51a024799afe9304b404255fe2021-12-02T12:40:39ZSubmolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism10.1038/s42003-020-01518-82399-3642https://doaj.org/article/443aebd51a024799afe9304b404255fe2020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01518-8https://doaj.org/toc/2399-3642Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better understanding of GPCR activation and signalling.Andra C. DumitruR. N. V. Krishna DeepakHeng LiuMelanie KoehlerCheng ZhangHao FanDavid AlsteensNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
description	Dumitru et al. probe the ligand-binding mechanism and activation of the human G protein-coupled C5a receptor (C5aR) and discover a cooperativity between the two orthosteric binding sites. Their findings, probing the dynamic aspects of receptor–ligand interaction, are valuable to develop a better understanding of GPCR activation and signalling.
format	article
author	Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens
author_facet	Andra C. Dumitru R. N. V. Krishna Deepak Heng Liu Melanie Koehler Cheng Zhang Hao Fan David Alsteens
author_sort	Andra C. Dumitru
title	Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
title_short	Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
title_full	Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
title_fullStr	Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
title_full_unstemmed	Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism
title_sort	submolecular probing of the complement c5a receptor–ligand binding reveals a cooperative two-site binding mechanism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/443aebd51a024799afe9304b404255fe
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Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

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