Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.

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Autores principales:	Viraj Deshpande, Jens Luebeck, Nam-Phuong D. Nguyen, Mehrdad Bakhtiari, Kristen M. Turner, Richard Schwab, Hannah Carter, Paul S. Mischel, Vineet Bafna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/45e5d01124ae4354be54fd8d47361b1f
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spelling	oai:doaj.org-article:45e5d01124ae4354be54fd8d47361b1f2021-12-02T14:35:51ZExploring the landscape of focal amplifications in cancer using AmpliconArchitect10.1038/s41467-018-08200-y2041-1723https://doaj.org/article/45e5d01124ae4354be54fd8d47361b1f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08200-yhttps://doaj.org/toc/2041-1723Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.Viraj DeshpandeJens LuebeckNam-Phuong D. NguyenMehrdad BakhtiariKristen M. TurnerRichard SchwabHannah CarterPaul S. MischelVineet BafnaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Viraj Deshpande Jens Luebeck Nam-Phuong D. Nguyen Mehrdad Bakhtiari Kristen M. Turner Richard Schwab Hannah Carter Paul S. Mischel Vineet Bafna Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
description	Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.
format	article
author	Viraj Deshpande Jens Luebeck Nam-Phuong D. Nguyen Mehrdad Bakhtiari Kristen M. Turner Richard Schwab Hannah Carter Paul S. Mischel Vineet Bafna
author_facet	Viraj Deshpande Jens Luebeck Nam-Phuong D. Nguyen Mehrdad Bakhtiari Kristen M. Turner Richard Schwab Hannah Carter Paul S. Mischel Vineet Bafna
author_sort	Viraj Deshpande
title	Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
title_short	Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
title_full	Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
title_fullStr	Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
title_full_unstemmed	Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
title_sort	exploring the landscape of focal amplifications in cancer using ampliconarchitect
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/45e5d01124ae4354be54fd8d47361b1f
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Exploring the landscape of focal amplifications in cancer using AmpliconArchitect

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