Predictability of evolutionary trajectories in fitness landscapes.

Experimental studies on enzyme evolution show that only a small fraction of all possible mutation trajectories are accessible to evolution. However, these experiments deal with individual enzymes and explore a tiny part of the fitness landscape. We report an exhaustive analysis of fitness landscapes...

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Bibliographic Details
Main Authors: Alexander E Lobkovsky, Yuri I Wolf, Eugene V Koonin
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
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Online Access:https://doaj.org/article/4a480d0839954830b8e1433829248b14
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