Dynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.
<h4>Background</h4>Mutations in the cellular prion protein associated to familial prion disorders severely increase the likelihood of its misfolding into pathogenic conformers. Despite their postulation as incompatible elements with the native fold, these mutations rarely modify the nati...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/4c1449f8e06a455685d2994273fbe0f2 |
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