Identical twins carry a persistent epigenetic signature of early genome programming
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues.
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Nature Portfolio
2021
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oai:doaj.org-article:4deb6641205f44abb1762c5892e3dccd2021-12-02T18:51:16ZIdentical twins carry a persistent epigenetic signature of early genome programming10.1038/s41467-021-25583-72041-1723https://doaj.org/article/4deb6641205f44abb1762c5892e3dccd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25583-7https://doaj.org/toc/2041-1723The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues.Jenny van DongenScott D. GordonAllan F. McRaeVeronika V. OdintsovaHamdi MbarekCharles E. BreezeKaren SugdenSara LundgrenJuan E. Castillo-FernandezEilis HannonTerrie E. MoffittFiona A. HagenbeekCatharina E. M. van BeijsterveldtJouke Jan HottengaPei-Chien TsaiBIOS ConsortiumGenetics of DNA Methylation ConsortiumJosine L. MinGibran HemaniErik A. EhliFranziska PaulClaudio D. SternBastiaan T. HeijmansP. Eline SlagboomLucia DaxingerSilvère M. van der MaarelEco J. C. de GeusGonneke WillemsenGrant W. MontgomeryBruno ReversadeMiina OllikainenJaakko KaprioTim D. SpectorJordana T. BellJonathan MillAvshalom CaspiNicholas G. MartinDorret I. BoomsmaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Jenny van Dongen Scott D. Gordon Allan F. McRae Veronika V. Odintsova Hamdi Mbarek Charles E. Breeze Karen Sugden Sara Lundgren Juan E. Castillo-Fernandez Eilis Hannon Terrie E. Moffitt Fiona A. Hagenbeek Catharina E. M. van Beijsterveldt Jouke Jan Hottenga Pei-Chien Tsai BIOS Consortium Genetics of DNA Methylation Consortium Josine L. Min Gibran Hemani Erik A. Ehli Franziska Paul Claudio D. Stern Bastiaan T. Heijmans P. Eline Slagboom Lucia Daxinger Silvère M. van der Maarel Eco J. C. de Geus Gonneke Willemsen Grant W. Montgomery Bruno Reversade Miina Ollikainen Jaakko Kaprio Tim D. Spector Jordana T. Bell Jonathan Mill Avshalom Caspi Nicholas G. Martin Dorret I. Boomsma Identical twins carry a persistent epigenetic signature of early genome programming |
| description |
The mechanisms underlying how monozygotic (or identical) twins arise are yet to be determined. Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues. |
| format |
article |
| author |
Jenny van Dongen Scott D. Gordon Allan F. McRae Veronika V. Odintsova Hamdi Mbarek Charles E. Breeze Karen Sugden Sara Lundgren Juan E. Castillo-Fernandez Eilis Hannon Terrie E. Moffitt Fiona A. Hagenbeek Catharina E. M. van Beijsterveldt Jouke Jan Hottenga Pei-Chien Tsai BIOS Consortium Genetics of DNA Methylation Consortium Josine L. Min Gibran Hemani Erik A. Ehli Franziska Paul Claudio D. Stern Bastiaan T. Heijmans P. Eline Slagboom Lucia Daxinger Silvère M. van der Maarel Eco J. C. de Geus Gonneke Willemsen Grant W. Montgomery Bruno Reversade Miina Ollikainen Jaakko Kaprio Tim D. Spector Jordana T. Bell Jonathan Mill Avshalom Caspi Nicholas G. Martin Dorret I. Boomsma |
| author_facet |
Jenny van Dongen Scott D. Gordon Allan F. McRae Veronika V. Odintsova Hamdi Mbarek Charles E. Breeze Karen Sugden Sara Lundgren Juan E. Castillo-Fernandez Eilis Hannon Terrie E. Moffitt Fiona A. Hagenbeek Catharina E. M. van Beijsterveldt Jouke Jan Hottenga Pei-Chien Tsai BIOS Consortium Genetics of DNA Methylation Consortium Josine L. Min Gibran Hemani Erik A. Ehli Franziska Paul Claudio D. Stern Bastiaan T. Heijmans P. Eline Slagboom Lucia Daxinger Silvère M. van der Maarel Eco J. C. de Geus Gonneke Willemsen Grant W. Montgomery Bruno Reversade Miina Ollikainen Jaakko Kaprio Tim D. Spector Jordana T. Bell Jonathan Mill Avshalom Caspi Nicholas G. Martin Dorret I. Boomsma |
| author_sort |
Jenny van Dongen |
| title |
Identical twins carry a persistent epigenetic signature of early genome programming |
| title_short |
Identical twins carry a persistent epigenetic signature of early genome programming |
| title_full |
Identical twins carry a persistent epigenetic signature of early genome programming |
| title_fullStr |
Identical twins carry a persistent epigenetic signature of early genome programming |
| title_full_unstemmed |
Identical twins carry a persistent epigenetic signature of early genome programming |
| title_sort |
identical twins carry a persistent epigenetic signature of early genome programming |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4deb6641205f44abb1762c5892e3dccd |
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