Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Glucocorticoid receptor (GR) regulates immunity and inflammation but the mechanisms by which GR represses proinflammatory genes are still being debated. Here the authors use a multidisciplinary approach and show that GR binds to a cryptic site within genome-wide NFκB DNA response elements to repress...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	William H. Hudson, Ian Mitchelle S. de Vera, Jerome C. Nwachukwu, Emily R. Weikum, Austin G. Herbst, Qin Yang, David L. Bain, Kendall W. Nettles, Douglas J. Kojetin, Eric A. Ortlund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4e26ab6d87a84291886bf3c3f88bfcfb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4e26ab6d87a84291886bf3c3f88bfcfb
record_format	dspace
spelling	oai:doaj.org-article:4e26ab6d87a84291886bf3c3f88bfcfb2021-12-02T15:34:17ZCryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements10.1038/s41467-018-03780-12041-1723https://doaj.org/article/4e26ab6d87a84291886bf3c3f88bfcfb2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03780-1https://doaj.org/toc/2041-1723Glucocorticoid receptor (GR) regulates immunity and inflammation but the mechanisms by which GR represses proinflammatory genes are still being debated. Here the authors use a multidisciplinary approach and show that GR binds to a cryptic site within genome-wide NFκB DNA response elements to repress pro-inflammatory genes.William H. HudsonIan Mitchelle S. de VeraJerome C. NwachukwuEmily R. WeikumAustin G. HerbstQin YangDavid L. BainKendall W. NettlesDouglas J. KojetinEric A. OrtlundNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William H. Hudson Ian Mitchelle S. de Vera Jerome C. Nwachukwu Emily R. Weikum Austin G. Herbst Qin Yang David L. Bain Kendall W. Nettles Douglas J. Kojetin Eric A. Ortlund Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
description	Glucocorticoid receptor (GR) regulates immunity and inflammation but the mechanisms by which GR represses proinflammatory genes are still being debated. Here the authors use a multidisciplinary approach and show that GR binds to a cryptic site within genome-wide NFκB DNA response elements to repress pro-inflammatory genes.
format	article
author	William H. Hudson Ian Mitchelle S. de Vera Jerome C. Nwachukwu Emily R. Weikum Austin G. Herbst Qin Yang David L. Bain Kendall W. Nettles Douglas J. Kojetin Eric A. Ortlund
author_facet	William H. Hudson Ian Mitchelle S. de Vera Jerome C. Nwachukwu Emily R. Weikum Austin G. Herbst Qin Yang David L. Bain Kendall W. Nettles Douglas J. Kojetin Eric A. Ortlund
author_sort	William H. Hudson
title	Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
title_short	Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
title_full	Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
title_fullStr	Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
title_full_unstemmed	Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
title_sort	cryptic glucocorticoid receptor-binding sites pervade genomic nf-κb response elements
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4e26ab6d87a84291886bf3c3f88bfcfb
work_keys_str_mv	AT williamhhudson crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT ianmitchellesdevera crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT jeromecnwachukwu crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT emilyrweikum crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT austingherbst crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT qinyang crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT davidlbain crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT kendallwnettles crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT douglasjkojetin crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements AT ericaortlund crypticglucocorticoidreceptorbindingsitespervadegenomicnfkbresponseelements
_version_	1718386898002509824

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Ejemplares similares