Exploring the sequence features determining amyloidosis in human antibody light chains

Abstract The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies into amyloid fibrils. There are plenty of computational resources available for the prediction of short aggregation-prone regions within proteins. However, it is still a challenging task to predict th...

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Auteurs principaux: Puneet Rawat, R. Prabakaran, Sandeep Kumar, M. Michael Gromiha
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/4fa62a20ac6040f6894d6f47565edcc3
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