A Genome-Wide Screen of Deletion Mutants in the Filamentous <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

A Genome-Wide Screen of Deletion Mutants in the Filamentous <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis

ABSTRACT Phagocytic cells such as macrophages play an important role in the host defense mechanisms mounted in response to the common human fungal pathogen Candida albicans. In vitro, C. albicans triggers macrophage NLRP3-Casp1/11-mediated pyroptosis, an inflammatory programmed cell death pathway. H...

Full description

Saved in:
Bibliographic Details
Main Authors: Kristy Koselny, Nebibe Mutlu, Annabel Y. Minard, Anuj Kumar, Damian J. Krysan, Melanie Wellington
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Candida albicans
inflammasome
pyroptosis
Microbiology
QR1-502
Online Access:https://doaj.org/article/5a846ae95af84dc7bb22353437472831
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/5a846ae95af84dc7bb22353437472831

Similar Items