Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating i...

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Autores principales:	Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03
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spelling	oai:doaj.org-article:5b06837f8ef2466591810930fcb8fa032021-12-02T16:50:09ZDifferential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b10.1038/s41467-018-05196-32041-1723https://doaj.org/article/5b06837f8ef2466591810930fcb8fa032018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05196-3https://doaj.org/toc/2041-1723In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146.Sunglim ChoHyang-Mi LeeI-Shing YuYoun Soo ChoiHsi-Yuan HuangSomaye Sadat HashemifarLing-Li LinMei-Chi ChenNikita D. AfanasievAly Azeem KhanShu-Wha LinAlexander Y. RudenskyShane CrottyLi-Fan LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sunglim Cho Hyang-Mi Lee I-Shing Yu Youn Soo Choi Hsi-Yuan Huang Somaye Sadat Hashemifar Ling-Li Lin Mei-Chi Chen Nikita D. Afanasiev Aly Azeem Khan Shu-Wha Lin Alexander Y. Rudensky Shane Crotty Li-Fan Lu Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
description	In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146.
format	article
author	Sunglim Cho Hyang-Mi Lee I-Shing Yu Youn Soo Choi Hsi-Yuan Huang Somaye Sadat Hashemifar Ling-Li Lin Mei-Chi Chen Nikita D. Afanasiev Aly Azeem Khan Shu-Wha Lin Alexander Y. Rudensky Shane Crotty Li-Fan Lu
author_facet	Sunglim Cho Hyang-Mi Lee I-Shing Yu Youn Soo Choi Hsi-Yuan Huang Somaye Sadat Hashemifar Ling-Li Lin Mei-Chi Chen Nikita D. Afanasiev Aly Azeem Khan Shu-Wha Lin Alexander Y. Rudensky Shane Crotty Li-Fan Lu
author_sort	Sunglim Cho
title	Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
title_short	Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
title_full	Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
title_fullStr	Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
title_full_unstemmed	Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
title_sort	differential cell-intrinsic regulations of germinal center b and t cells by mir-146a and mir-146b
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03
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Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

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