Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b
In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating i...
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Main Authors: | Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
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Subjects: | |
Online Access: | https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03 |
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