Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating i...

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Main Authors: Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03
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https://doaj.org/article/5b06837f8ef2466591810930fcb8fa03

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