A secondary RET mutation in the activation loop conferring resistance to vandetanib
Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the...
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Nature Portfolio
2018
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oai:doaj.org-article:5dda588c6b064bfcbe3ac0b3c008bd632021-12-02T17:33:17ZA secondary RET mutation in the activation loop conferring resistance to vandetanib10.1038/s41467-018-02994-72041-1723https://doaj.org/article/5dda588c6b064bfcbe3ac0b3c008bd632018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02994-7https://doaj.org/toc/2041-1723Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase.Takashi NakaokuTakashi KohnoMitsugu ArakiSeiji NihoRakhee ChauhanPhillip P. KnowlesKatsuya TsuchiharaShingo MatsumotoYoko ShimadaSachiyo MimakiGenichiro IshiiHitoshi IchikawaSatoru NagatoishiKouhei TsumotoYasushi OkunoKiyotaka YohNeil Q. McDonaldKoichi GotoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Takashi Nakaoku Takashi Kohno Mitsugu Araki Seiji Niho Rakhee Chauhan Phillip P. Knowles Katsuya Tsuchihara Shingo Matsumoto Yoko Shimada Sachiyo Mimaki Genichiro Ishii Hitoshi Ichikawa Satoru Nagatoishi Kouhei Tsumoto Yasushi Okuno Kiyotaka Yoh Neil Q. McDonald Koichi Goto A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| description |
Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase. |
| format |
article |
| author |
Takashi Nakaoku Takashi Kohno Mitsugu Araki Seiji Niho Rakhee Chauhan Phillip P. Knowles Katsuya Tsuchihara Shingo Matsumoto Yoko Shimada Sachiyo Mimaki Genichiro Ishii Hitoshi Ichikawa Satoru Nagatoishi Kouhei Tsumoto Yasushi Okuno Kiyotaka Yoh Neil Q. McDonald Koichi Goto |
| author_facet |
Takashi Nakaoku Takashi Kohno Mitsugu Araki Seiji Niho Rakhee Chauhan Phillip P. Knowles Katsuya Tsuchihara Shingo Matsumoto Yoko Shimada Sachiyo Mimaki Genichiro Ishii Hitoshi Ichikawa Satoru Nagatoishi Kouhei Tsumoto Yasushi Okuno Kiyotaka Yoh Neil Q. McDonald Koichi Goto |
| author_sort |
Takashi Nakaoku |
| title |
A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| title_short |
A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| title_full |
A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| title_fullStr |
A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| title_full_unstemmed |
A secondary RET mutation in the activation loop conferring resistance to vandetanib |
| title_sort |
secondary ret mutation in the activation loop conferring resistance to vandetanib |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/5dda588c6b064bfcbe3ac0b3c008bd63 |
| work_keys_str_mv |
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