The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

ABSTRACT Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associa...

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Autores principales: Gillian M. Fisher, Simon A. Cobbold, Andrew Jezewski, Emma F. Carpenter, Megan Arnold, Annie N. Cowell, Erick T. Tjhin, Kevin J. Saliba, Tina S. Skinner-Adams, Marcus C. S. Lee, Audrey Odom John, Elizabeth A. Winzeler, Malcolm J. McConville, Sally-Ann Poulsen, Katherine T. Andrews
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Plasmodium falciparum
drug resistance mechanisms
drug targets
glycolysis
metabolic regulation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/610827e8ff5a4ac08e02462e0f5e26af
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https://doaj.org/article/610827e8ff5a4ac08e02462e0f5e26af

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