The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides
ABSTRACT Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associa...
Guardado en:
Autores principales: | Gillian M. Fisher, Simon A. Cobbold, Andrew Jezewski, Emma F. Carpenter, Megan Arnold, Annie N. Cowell, Erick T. Tjhin, Kevin J. Saliba, Tina S. Skinner-Adams, Marcus C. S. Lee, Audrey Odom John, Elizabeth A. Winzeler, Malcolm J. McConville, Sally-Ann Poulsen, Katherine T. Andrews |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
American Society for Microbiology
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/610827e8ff5a4ac08e02462e0f5e26af |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>
por: Laure Dumont, et al.
Publicado: (2019) -
Suppression of Drug Resistance Reveals a Genetic Mechanism of Metabolic Plasticity in Malaria Parasites
por: Ann M. Guggisberg, et al.
Publicado: (2018) -
Malaria: revisión retrospectiva de 12 casos no autóctonos en Chile
por: Pérez C,Carlos, et al.
Publicado: (2006) -
Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness
por: Satish K. Dhingra, et al.
Publicado: (2019) -
<named-content content-type="genus-species">Plasmodium falciparum</named-content> Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
por: Kirthana M. V. Sindhe, et al.
Publicado: (2020)