Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats

Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic s...

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Autores principales:	Nikhil S. Bhandarkar, Peter Mouatt, Marwan E. Majzoub, Torsten Thomas, Lindsay Brown, Sunil K. Panchal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	coffee pulp chlorogenic acid obesity metabolic syndrome high-carbohydrate high-fat Medicine R
Acceso en línea:	https://doaj.org/article/624150904433409783a84115bbdcf1b7
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spelling	oai:doaj.org-article:624150904433409783a84115bbdcf1b72021-11-25T18:37:41ZCoffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats10.3390/pathogens101113692076-0817https://doaj.org/article/624150904433409783a84115bbdcf1b72021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1369https://doaj.org/toc/2076-0817Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic syndrome induced by high-carbohydrate, high-fat diet in rats by dietary supplementation with 5% freeze-dried coffee pulp for the final 8 weeks of a 16-week protocol. Coffee pulp decreased body weight, feed efficiency and abdominal fat; normalised systolic blood pressure, left ventricular diastolic stiffness, and plasma concentrations of triglycerides and non-esterified fatty acids; and improved glucose tolerance in rats fed high-carbohydrate, high-fat diet. Further, the gut microbiota was modulated with high-carbohydrate, high-fat diet and coffee pulp supplementation and 14 physiological parameters were correlated with the changes in bacterial community structures. This study suggested that coffee pulp, as a waste from the coffee industry, is useful as a functional food for improving obesity-associated metabolic, cardiovascular and liver structure and function, and gut microbiota.Nikhil S. BhandarkarPeter MouattMarwan E. MajzoubTorsten ThomasLindsay BrownSunil K. PanchalMDPI AGarticlecoffee pulpchlorogenic acidobesitymetabolic syndromehigh-carbohydratehigh-fatMedicineRENPathogens, Vol 10, Iss 1369, p 1369 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coffee pulp chlorogenic acid obesity metabolic syndrome high-carbohydrate high-fat Medicine R
spellingShingle	coffee pulp chlorogenic acid obesity metabolic syndrome high-carbohydrate high-fat Medicine R Nikhil S. Bhandarkar Peter Mouatt Marwan E. Majzoub Torsten Thomas Lindsay Brown Sunil K. Panchal Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
description	Waste from food production can be re-purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caffeine, chlorogenic acid, trigonelline, diterpenes and fibre. We investigated the attenuation of signs of metabolic syndrome induced by high-carbohydrate, high-fat diet in rats by dietary supplementation with 5% freeze-dried coffee pulp for the final 8 weeks of a 16-week protocol. Coffee pulp decreased body weight, feed efficiency and abdominal fat; normalised systolic blood pressure, left ventricular diastolic stiffness, and plasma concentrations of triglycerides and non-esterified fatty acids; and improved glucose tolerance in rats fed high-carbohydrate, high-fat diet. Further, the gut microbiota was modulated with high-carbohydrate, high-fat diet and coffee pulp supplementation and 14 physiological parameters were correlated with the changes in bacterial community structures. This study suggested that coffee pulp, as a waste from the coffee industry, is useful as a functional food for improving obesity-associated metabolic, cardiovascular and liver structure and function, and gut microbiota.
format	article
author	Nikhil S. Bhandarkar Peter Mouatt Marwan E. Majzoub Torsten Thomas Lindsay Brown Sunil K. Panchal
author_facet	Nikhil S. Bhandarkar Peter Mouatt Marwan E. Majzoub Torsten Thomas Lindsay Brown Sunil K. Panchal
author_sort	Nikhil S. Bhandarkar
title	Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
title_short	Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
title_full	Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
title_fullStr	Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
title_full_unstemmed	Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats
title_sort	coffee pulp, a by-product of coffee production, modulates gut microbiota and improves metabolic syndrome in high-carbohydrate, high-fat diet-fed rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/624150904433409783a84115bbdcf1b7
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Coffee Pulp, a By-Product of Coffee Production, Modulates Gut Microbiota and Improves Metabolic Syndrome in High-Carbohydrate, High-Fat Diet-Fed Rats

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