SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(−/−) Mice

SHANK2 (ProSAP1) is a postsynaptic scaffolding protein of excitatory synapses in the central nervous system and implicated in the development of autism spectrum disorders (ASD). Patients with mutations in SHANK2 show autism-like behaviors, developmental delay, and intellectual disability. We generat...

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Autores principales: Anne-Kathrin Lutz, Andrea Pérez Arévalo, Valentin Ioannidis, Nadine Stirmlinger, Maria Demestre, Richard Delorme, Thomas Bourgeron, Tobias M. Boeckers
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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ASD
Acceso en línea:https://doaj.org/article/62de73e79ade401bb205c8be84ad16a1
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