SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

Targeted inhibition of the ERK-MAPK pathway is challenged by the development of resistance and toxicity. Here, the authors show that SHOC2 genetic inhibition impairs lung tumour development and improves MEK inhibitor efficacy in RAS- and EGFR-mutant cells.

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Autores principales:	Greg G. Jones, Isabel Boned del Río, Sibel Sari, Aysen Sekerim, Lucy C. Young, Nicole Hartig, Itziar Areso Zubiaur, Mona A. El-Bahrawy, Rob E. Hynds, Winnie Lei, Miriam Molina-Arcas, Julian Downward, Pablo Rodriguez-Viciana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63c728d50eef448aa2fdb9117a059704
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spelling	oai:doaj.org-article:63c728d50eef448aa2fdb9117a0597042021-12-02T15:35:26ZSHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers10.1038/s41467-019-10367-x2041-1723https://doaj.org/article/63c728d50eef448aa2fdb9117a0597042019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10367-xhttps://doaj.org/toc/2041-1723Targeted inhibition of the ERK-MAPK pathway is challenged by the development of resistance and toxicity. Here, the authors show that SHOC2 genetic inhibition impairs lung tumour development and improves MEK inhibitor efficacy in RAS- and EGFR-mutant cells.Greg G. JonesIsabel Boned del RíoSibel SariAysen SekerimLucy C. YoungNicole HartigItziar Areso ZubiaurMona A. El-BahrawyRob E. HyndsWinnie LeiMiriam Molina-ArcasJulian DownwardPablo Rodriguez-VicianaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Greg G. Jones Isabel Boned del Río Sibel Sari Aysen Sekerim Lucy C. Young Nicole Hartig Itziar Areso Zubiaur Mona A. El-Bahrawy Rob E. Hynds Winnie Lei Miriam Molina-Arcas Julian Downward Pablo Rodriguez-Viciana SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
description	Targeted inhibition of the ERK-MAPK pathway is challenged by the development of resistance and toxicity. Here, the authors show that SHOC2 genetic inhibition impairs lung tumour development and improves MEK inhibitor efficacy in RAS- and EGFR-mutant cells.
format	article
author	Greg G. Jones Isabel Boned del Río Sibel Sari Aysen Sekerim Lucy C. Young Nicole Hartig Itziar Areso Zubiaur Mona A. El-Bahrawy Rob E. Hynds Winnie Lei Miriam Molina-Arcas Julian Downward Pablo Rodriguez-Viciana
author_facet	Greg G. Jones Isabel Boned del Río Sibel Sari Aysen Sekerim Lucy C. Young Nicole Hartig Itziar Areso Zubiaur Mona A. El-Bahrawy Rob E. Hynds Winnie Lei Miriam Molina-Arcas Julian Downward Pablo Rodriguez-Viciana
author_sort	Greg G. Jones
title	SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
title_short	SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
title_full	SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
title_fullStr	SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
title_full_unstemmed	SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers
title_sort	shoc2 phosphatase-dependent raf dimerization mediates resistance to mek inhibition in ras-mutant cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/63c728d50eef448aa2fdb9117a059704
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SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

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