A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

The antibiotic pyrazinamide is central to tuberculosis treatment regimens, globally. Despite its efficacy, resistance to the drug is increasing. Here, Eric Rubin and colleagues characterise the genetic basis of pyrazinamide resistance.

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Autores principales: Adam N. Yadon, Kashmeel Maharaj, John H. Adamson, Yi-Pin Lai, James C. Sacchettini, Thomas R. Ioerger, Eric J. Rubin, Alexander S. Pym
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/64b393ee6e854aef8a3dc9823de250ff
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