Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.

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Autores principales:	Thanos P. Mourikis, Lorena Benedetti, Elizabeth Foxall, Damjan Temelkovski, Joel Nulsen, Juliane Perner, Matteo Cereda, Jesper Lagergren, Michael Howell, Christopher Yau, Rebecca C. Fitzgerald, Paola Scaffidi, The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Francesca D. Ciccarelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6525c04e989d4f92801eb2e25637bf6b
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spelling	oai:doaj.org-article:6525c04e989d4f92801eb2e25637bf6b2021-12-02T16:57:09ZPatient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma10.1038/s41467-019-10898-32041-1723https://doaj.org/article/6525c04e989d4f92801eb2e25637bf6b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10898-3https://doaj.org/toc/2041-1723Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.Thanos P. MourikisLorena BenedettiElizabeth FoxallDamjan TemelkovskiJoel NulsenJuliane PernerMatteo CeredaJesper LagergrenMichael HowellChristopher YauRebecca C. FitzgeraldPaola ScaffidiThe Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) ConsortiumFrancesca D. CiccarelliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thanos P. Mourikis Lorena Benedetti Elizabeth Foxall Damjan Temelkovski Joel Nulsen Juliane Perner Matteo Cereda Jesper Lagergren Michael Howell Christopher Yau Rebecca C. Fitzgerald Paola Scaffidi The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium Francesca D. Ciccarelli Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
description	Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.
format	article
author	Thanos P. Mourikis Lorena Benedetti Elizabeth Foxall Damjan Temelkovski Joel Nulsen Juliane Perner Matteo Cereda Jesper Lagergren Michael Howell Christopher Yau Rebecca C. Fitzgerald Paola Scaffidi The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium Francesca D. Ciccarelli
author_facet	Thanos P. Mourikis Lorena Benedetti Elizabeth Foxall Damjan Temelkovski Joel Nulsen Juliane Perner Matteo Cereda Jesper Lagergren Michael Howell Christopher Yau Rebecca C. Fitzgerald Paola Scaffidi The Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium Francesca D. Ciccarelli
author_sort	Thanos P. Mourikis
title	Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
title_short	Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
title_full	Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
title_fullStr	Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
title_full_unstemmed	Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
title_sort	patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6525c04e989d4f92801eb2e25637bf6b
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Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma

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