Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

Seiya Oura and Taichi Noda et al. overcome the challenge of gene editing in CAG repeats, such as those causing Huntington’s Disease, using their recently developed SpCas9-NG variant. They demonstrate that SpCas9-NG can precisely edit and contract the CAG repeat tracks in a Huntington’s Disease mouse...

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Autores principales:	Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6b8b24cc62624b4fbbeec478f8cf925c
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spelling	oai:doaj.org-article:6b8b24cc62624b4fbbeec478f8cf925c2021-12-02T16:05:53ZPrecise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG10.1038/s42003-021-02304-w2399-3642https://doaj.org/article/6b8b24cc62624b4fbbeec478f8cf925c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02304-whttps://doaj.org/toc/2399-3642Seiya Oura and Taichi Noda et al. overcome the challenge of gene editing in CAG repeats, such as those causing Huntington’s Disease, using their recently developed SpCas9-NG variant. They demonstrate that SpCas9-NG can precisely edit and contract the CAG repeat tracks in a Huntington’s Disease mouse model, opening new avenues for research in this disease.Seiya OuraTaichi NodaNaoko MorimuraSeiji HitoshiHiroshi NishimasuYoshitaka NagaiOsamu NurekiMasahito IkawaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Seiya Oura Taichi Noda Naoko Morimura Seiji Hitoshi Hiroshi Nishimasu Yoshitaka Nagai Osamu Nureki Masahito Ikawa Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
description	Seiya Oura and Taichi Noda et al. overcome the challenge of gene editing in CAG repeats, such as those causing Huntington’s Disease, using their recently developed SpCas9-NG variant. They demonstrate that SpCas9-NG can precisely edit and contract the CAG repeat tracks in a Huntington’s Disease mouse model, opening new avenues for research in this disease.
format	article
author	Seiya Oura Taichi Noda Naoko Morimura Seiji Hitoshi Hiroshi Nishimasu Yoshitaka Nagai Osamu Nureki Masahito Ikawa
author_facet	Seiya Oura Taichi Noda Naoko Morimura Seiji Hitoshi Hiroshi Nishimasu Yoshitaka Nagai Osamu Nureki Masahito Ikawa
author_sort	Seiya Oura
title	Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
title_short	Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
title_full	Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
title_fullStr	Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
title_full_unstemmed	Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG
title_sort	precise cag repeat contraction in a huntington’s disease mouse model is enabled by gene editing with spcas9-ng
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6b8b24cc62624b4fbbeec478f8cf925c
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Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

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