Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain

Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain

Summary: Infections typically begin with pathogens adhering to host cells. For bacteria, this adhesion can occur through specific ligand-binding domains. We identify a 20-kDa peptide-binding domain (PBD) in a 1.5-MDa RTX adhesin of a Gram-negative marine bacterium that colonizes diatoms. The crystal...

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Bibliographic Details
Main Authors: Shuaiqi Guo, Hossein Zahiri, Corey Stevens, Daniel C. Spaanderman, Lech-Gustav Milroy, Christian Ottmann, Luc Brunsveld, Ilja K. Voets, Peter L. Davies
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
structural biology
bacteria-host interaction
bacterial adhesins
X-ray crystallography
peptide inhibitors
peptide-binding domain
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/6c8e93c1682b4badaad38e01db08d15d
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https://doaj.org/article/6c8e93c1682b4badaad38e01db08d15d

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