T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cell receptors are geared towards recognition of HLA-D...

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Auteurs principaux:	Mai T. Tran, Pouya Faridi, Jia Jia Lim, Yi Tian Ting, Goodluck Onwukwe, Pushpak Bhattacharjee, Claerwen M. Jones, Eleonora Tresoldi, Fergus J. Cameron, Nicole L. La Gruta, Anthony W. Purcell, Stuart I. Mannering, Jamie Rossjohn, Hugh H. Reid
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
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id	oai:doaj.org-article:6cfc61766a5b4c9d973ece4ad2e9ab57
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spelling	oai:doaj.org-article:6cfc61766a5b4c9d973ece4ad2e9ab572021-12-02T16:34:55ZT cell receptor recognition of hybrid insulin peptides bound to HLA-DQ810.1038/s41467-021-25404-x2041-1723https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab572021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25404-xhttps://doaj.org/toc/2041-1723Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cell receptors are geared towards recognition of HLA-DQ8 bound hybrid peptides in patients with type 1 diabetes.Mai T. TranPouya FaridiJia Jia LimYi Tian TingGoodluck OnwukwePushpak BhattacharjeeClaerwen M. JonesEleonora TresoldiFergus J. CameronNicole L. La GrutaAnthony W. PurcellStuart I. ManneringJamie RossjohnHugh H. ReidNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mai T. Tran Pouya Faridi Jia Jia Lim Yi Tian Ting Goodluck Onwukwe Pushpak Bhattacharjee Claerwen M. Jones Eleonora Tresoldi Fergus J. Cameron Nicole L. La Gruta Anthony W. Purcell Stuart I. Mannering Jamie Rossjohn Hugh H. Reid T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
description	Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cell receptors are geared towards recognition of HLA-DQ8 bound hybrid peptides in patients with type 1 diabetes.
format	article
author	Mai T. Tran Pouya Faridi Jia Jia Lim Yi Tian Ting Goodluck Onwukwe Pushpak Bhattacharjee Claerwen M. Jones Eleonora Tresoldi Fergus J. Cameron Nicole L. La Gruta Anthony W. Purcell Stuart I. Mannering Jamie Rossjohn Hugh H. Reid
author_facet	Mai T. Tran Pouya Faridi Jia Jia Lim Yi Tian Ting Goodluck Onwukwe Pushpak Bhattacharjee Claerwen M. Jones Eleonora Tresoldi Fergus J. Cameron Nicole L. La Gruta Anthony W. Purcell Stuart I. Mannering Jamie Rossjohn Hugh H. Reid
author_sort	Mai T. Tran
title	T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
title_short	T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
title_full	T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
title_fullStr	T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
title_full_unstemmed	T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
title_sort	t cell receptor recognition of hybrid insulin peptides bound to hla-dq8
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
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T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

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