T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

Epitopes formed by fusion of more than one self peptide, such as proinsulin and other β cell proteins, can result in the formation of non-self hybrid peptides that can potentially trigger autoimmune responses. Here the authors show how TRBV5 + T cell receptors are geared towards recognition of HLA-D...

Full description

Saved in:
Bibliographic Details
Main Authors: Mai T. Tran, Pouya Faridi, Jia Jia Lim, Yi Tian Ting, Goodluck Onwukwe, Pushpak Bhattacharjee, Claerwen M. Jones, Eleonora Tresoldi, Fergus J. Cameron, Nicole L. La Gruta, Anthony W. Purcell, Stuart I. Mannering, Jamie Rossjohn, Hugh H. Reid
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/6cfc61766a5b4c9d973ece4ad2e9ab57
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items