Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
Disease heritability and genetic correlations between traits depend on genetics, the environment and their interaction. Here, Jia et al. compute disease prevalence curves and disease embeddings from electronic health records and impute heritability for hundreds of diseases and genetic correlations f...
Enregistré dans:
Auteurs principaux: | Gengjie Jia, Yu Li, Hanxin Zhang, Ishanu Chattopadhyay, Anders Boeck Jensen, David R. Blair, Lea Davis, Peter N. Robinson, Torsten Dahlén, Søren Brunak, Mikael Benson, Gustaf Edgren, Nancy J. Cox, Xin Gao, Andrey Rzhetsky |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/6d34b36c86004f14891b25d4276eebf5 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Studies on Genetic Variability, Heritability and Genetic Advance in Chrysanthemum
par: V Baskaran, et autres
Publié: (2009) -
Genetic variability and heritability of acid-adaptive soybean promising lines
par: HERU KUSWANTORO
Publié: (2017) -
Genetic Variability and Heritability for Growth and Yield in Cucumber (Cucumis sativus L.)
par: N Pushpalatha, et autres
Publié: (2016) -
Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments.
par: Jingshu Wang, et autres
Publié: (2021) -
Agronomic characters, genetic and phenotypic diversity coefficients, and heritability of 12 genotypes of rice
par: Jaenudin Kartahadimaja, et autres
Publié: (2021)